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Updated: Jan 28, 2026
08:51
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
16.5K
Recent Progress of Polymeric Nanogels for Gene Delivery
Rima Kandil1, Olivia M Merkel1
1Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-University, Butenandtstraße 5-13, 81337, Munich, Germany.
Current Opinion in Colloid & Interface Science
|March 12, 2019
Summary
Polymeric nanogels show promise for delivering genetic material in gene therapy, overcoming challenges with nucleic acid delivery. This review explores recent advancements and future directions for nanogel-based gene delivery systems.
Area of Science:
- Biotechnology
- Materials Science
- Pharmacology
Background:
- Gene therapy holds significant potential but faces delivery challenges.
- Nucleic acids have poor pharmaceutical properties, hindering intracellular delivery.
- Polymeric nanogels offer a promising solution for oligonucleotide delivery.
Purpose of the Study:
- To summarize recent progress in using nanogels for gene delivery.
- To discuss various types of modified nanogels for enhanced gene delivery.
- To critically evaluate key aspects and future challenges in nanogel-based gene delivery.
Main Methods:
- Literature review of nanogel applications in gene delivery.
- Analysis of modified, stimuli-responsive, targeted, and co-delivering nanogels.
- Discussion of critical factors for successful gene delivery using nanogels.
Main Results:
- Nanogels are effective platforms for delivering genetic material.
- Modified nanogels demonstrate improved targeting and responsiveness.
- Recent advancements show progress in overcoming gene delivery hurdles.
Conclusions:
- Polymeric nanogels are a viable and advancing technology for gene therapy delivery.
- Further research is needed to address remaining challenges in nanogel-based gene delivery.
- Nanogels offer a versatile platform for developing next-generation gene therapies.
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