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Updated: Jan 28, 2026

RNA Interference-based Investigation of the Function of Heat Shock Protein 27 during Corneal Epithelial Wound Healing
Published on: September 27, 2016
Access to 27-Nortomatidine and 27-Norsoladulcidine Derivatives
Dorota Czajkowska-Szczykowska1, Alejandro Corona Díaz2, Grzegorz Aleksiejczuk1
1Institute of Chemistry , University of Bialystok , K. Ciołkowskiego 1 K , 15-245 Białystok , Poland.
Abstract:
Synthesis of (22 R)- and (22 S)-27-norspirosolane alkaloids from tigogenin, epismilagenin, and smilagenin is described. The alkaloids were prepared from readily available dinorcholanic lactones via their reaction with 4-chlorobutyllithium followed by substitution of chloride with azide and reductive N-cyclization under the Staudinger conditions.
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