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Updated: Jan 28, 2026

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
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Locomotion-dependent remapping of distributed cortical networks.

Kelly B Clancy1,2, Ivana Orsolic3,4, Thomas D Mrsic-Flogel5,6

  • 1Biozentrum, University of Basel, Basel, Switzerland. k.clancy@ucl.ac.uk.

Nature Neuroscience
|March 13, 2019
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Summary
This summary is machine-generated.

Individual neurons in the brain connect differently to widespread network activity, with these connections changing during locomotion. This study reveals how neural coupling shifts between visual (V1) and retrosplenial (RSP) cortex during running.

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • Neocortical interactions are dynamic and state-dependent.
  • Understanding how individual neurons integrate into large-scale brain networks is crucial but challenging.

Purpose of the Study:

  • To investigate how individual neurons in primary visual (V1) and retrosplenial (RSP) cortex couple to cortex-wide network dynamics.
  • To determine if and how these neuronal coupling patterns change with brain state, specifically during locomotion.

Main Methods:

  • Simultaneous recording of single-unit spiking in V1 and RSP with widefield calcium imaging of dorsal cortical activity.
  • Correlation analysis to map neuronal spiking to spatially distributed network activity patterns.
  • Analysis of changes in neuronal coupling patterns during locomotion compared to rest.

Main Results:

  • Neurons exhibited distinct and reproducible patterns of coupling to cortical activity, ranging from local to distal.
  • The degree of distal coupling was predictable based on local network correlation.
  • Locomotion altered neuronal coupling: V1 neurons showed increased affiliation with higher visual and motor areas, while RSP neurons strengthened connections with sensory cortices.

Conclusions:

  • Individual neurons display diverse coupling strategies to cortex-wide activity.
  • Locomotion restructures these neuronal coupling patterns in an area-specific manner.
  • This restructuring suggests a shift in the mode of cortical processing during locomotion.