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[Neuroendocrine hiperplasia in linfocitic and ulcerative colitis]
Fernando Arévalo1, Eduardo Monge2, Fiorella Zurita3
1Servicio Patología, Hospital Nacional Daniel Alcides Carrión. Callao, Perú; Universidad Nacional Mayor de San Marcos. Lima, Perú.
Introduction:
Some authors have found increase of neuroendocrine cells in microscopic colitis and ulcerative colitis.
Objective:
The aim of this study is to evaluate the presence of neuroendocrine cells in ulcerative colitis and lymphocytic colitis and collagenous colitis.
Materials And Methods:
Immunohistochemistry was performed to identify neuroendocrine cells through marker chromogranin A (CgA). The study included 10 cases of each diagnosis of Lymphocytic colitis, collagenous colitis and ulcerative colitis.
Results:
There was statistically significant difference in the count of neuroendocrine cells, between lymphocytic colitis and control (p=0.019104), and between ulcerative colitis and controls (p=0.0077). In collagenous colitis there was an increase in neuroendocrine cells but we failed to find statistical differences.
Conclusion:
We could observe neuroendocrine cell hyperplasia in lymphocytic colitis and ulcerative colitis compared with controls, which confirm previous studies.
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