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[Helicobacter pylori, nodular gastritis and premalignant stomach lesions: a case-control study]
Hernando Marulanda1, William Otero1, Martín Gómez2
1Universidad Nacional de Colombia, Hospital Universitario Nacional. Bogotá, Colombia.
Insights
Nodular gastritis patients are younger and frequently infected with Helicobacter pylori. Investigating and eradicating H. pylori is recommended for those with nodular gastritis.
Area of Science:
- Gastroenterology
- Oncology
- Infectious Diseases
Background:
- Nodular gastritis (GN) is linked to Helicobacter pylori (H. pylori) infection and may increase gastric cancer risk.
- GN is prevalent in children with H. pylori but understudied in Colombia.
- This study investigates nodular gastritis in Colombian adults.
Purpose of the Study:
- To compare characteristics of patients with nodular gastritis versus those with chronic gastritis without lymphoid follicles.
- To determine the prevalence of H. pylori in nodular gastritis.
- To assess the association between nodular gastritis and gastric cancer.
Main Methods:
- A case-control study involving 344 adult patients undergoing upper digestive endoscopy.
- Cases had endoscopic and histological nodular gastritis; controls had chronic gastritis without lymphoid follicles.
- The Operative Link for Gastritis Assessment (OLGA) system was used for staging.
Main Results:
- Nodular gastritis patients were younger (40.9 vs 50.9 years) and had significantly higher H. pylori prevalence (91.9% vs 47.8%).
- Lymphoid follicles were more common in the antrum than the body.
- OLGA stage II was more frequent in nodular gastritis cases (6.4% vs 1.2%). Gastric cancer was identified in cases.
Conclusions:
- Nodular gastritis is associated with younger age and high H. pylori infection rates.
- H. pylori investigation and eradication are recommended for patients diagnosed with nodular gastritis.
Introduction:
Nodular gastritis (GN) is a type of gastritis strongly related to Helicobacter pylori and may be a risk factor for gastric cancer. It is a highly prevalent pathology in children infected with H. pylori. In Colombia there are no studies on this entity and for this reason we decided to carry out the present investigation.
Materials And Methods:
Case studies and controls. Case; endoscopic and histological nodular gastritis, controls, chronic gastritis without lymphoid follicles to histology.
Population:
adults older than 18 years, who underwent a high digestive endoscopy and signed informed consent. All patients were biopsied with the OLGA system.
Results:
We included 344 patients, 172 in each group. The cases had 10 years less than the controls (40.9 vs 50.9, p = 0.045). In the cases H. pylori was found in 91.9% vs 47.8% (p <0.001). Lymphoid follicles were more frequent in the antrum than in the body (60.5 vs 4.7% p < 0.00001). OLGA II in cases 6.4% versus 1.2% (p = 0.01), OLGA III was similar. There was no OLGA IV in any patient. In the cases a gastric cancer was found.
Conclusions:
Patients with nodular gastritis are younger than controls. 92% of the cases had H. pylori.
Recommendations:
It is recommended that this infection be investigated and eradicated in patients with this type of gastritis.
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