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A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Selective amidation by a photocatalyzed umpolung reaction
Debasish Ghosh1, Rajesh Nandi1, Saikat Khamarui2
1Department of Chemistry, University of Calcutta, 92 A. P. C. Road, Kolkata-700009, India. dkmchem@caluniv.ac.in.
Abstract:
A metal-catalyzed organic transformation merged with another organophotocatalyst has been developed under mild conditions for production of α-ketoamides. CuI-catalyzed highly selective and rapid COCH2-amidation in the presence of electrophilic Cα[double bond, length as m-dash]O bonds, which is synchronized by an eosin Y (EY)-photocatalyst, furnishes a wide range of labile α-ketoamides, unsymmetrical oxalamides and chiral analogues on the treatment of 1,3-dicarbonyls with amines, PhIO and LED light at room temperature. The current strategy opens up a new avenue to making photocatalysis a common synthetic tool for large-scale production in academia and industry.
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