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Quality of Life Changes After Chronic Total Occlusion Angioplasty in Patients With Baseline Refractory Angina

Taishi Hirai1,2, J Aaron Grantham1,2, James Sapontis3

  • 1Saint Luke's Mid America Heart Institute, Kansas City, MO (T.H., J.A.G., D.J.C., K.N., K.L.G., J.A.S., A.C.S.).

Circulation. Cardiovascular Interventions
|March 16, 2019
PubMed

Insights

Chronic total occlusion percutaneous coronary intervention significantly improves quality of life for patients with refractory angina. Successful procedures led to greater health status improvements compared to unsuccessful ones, persisting for one year.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Health Outcomes Research

Background:

  • Refractory angina significantly impacts patient quality of life.
  • Limited data exists on health status improvements after chronic total occlusion percutaneous coronary intervention (CTO PCI) in this population.

Purpose of the Study:

  • To evaluate the degree of quality of life improvement after CTO PCI in patients experiencing refractory angina.

Main Methods:

  • A 12-center registry of 1000 patients undergoing CTO PCI was analyzed.
  • Refractory angina was defined as persistent symptoms despite ≥3 antianginal medications.
  • Health status was measured using the Seattle Angina Questionnaire (SAQ) at baseline and 1-year follow-up.

Main Results:

  • 14.8% of patients had refractory angina at baseline.
  • Technical success was 81.1% with a 6.8% rate of major adverse cardiac and cerebral events.
  • Successful CTO PCI patients showed significantly greater improvements in SAQ Angina Frequency and Summary Scores compared to unsuccessful cases.

Conclusions:

  • CTO PCI offers substantial and clinically significant health status improvements for patients with refractory angina.
  • These improvements are sustained through 12 months post-procedure.
  • Procedural success in CTO PCI correlates with enhanced health status recovery.
Abstract

Keywords:
chronic total occlusiondyspneahealth statuspercutaneous coronary interventionquality of liferefractory anginaregistry

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