Related Experiment Video
Updated: Jan 27, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.7K
The Current Landscape of Treatment in Non-Metastatic Castration-Resistant Prostate Cancer.
Joelle El-Amm1, Jeanny B Aragon-Ching2
1Hematology and Oncology, Lebanese American University, Beirut, Lebanon.
Clinical Medicine Insights. Oncology
|March 16, 2019
Summary
Novel anti-androgens like apalutamide and enzalutamide offer new hope for non-metastatic castration-resistant prostate cancer (nmCRPC). This review covers pivotal trials and discusses the benefits and challenges of these advanced prostate cancer treatments.
Area of Science:
- Oncology
- Urology
- Medical Science
Background:
- Non-metastatic castration-resistant prostate cancer (nmCRPC) presents a significant unmet need in advanced prostate cancer management.
- The disease is characterized by heterogeneity and variable progression to overt metastases.
- Historically, treatment options for nmCRPC were limited.
Purpose of the Study:
- To review pivotal clinical trials leading to the FDA approval of apalutamide and enzalutamide for nmCRPC.
- To explore early data on the efficacy of darolutamide in this patient population.
- To discuss the promises and challenges associated with novel anti-androgen therapies in nmCRPC.
Main Methods:
- Review of pivotal clinical trials for apalutamide and enzalutamide in nmCRPC.
- Analysis of early data for darolutamide in nmCRPC.
- Discussion of treatment benefits and challenges based on trial outcomes.
Main Results:
- Apalutamide and enzalutamide have demonstrated significant metastasis-free survival benefits in nmCRPC.
- These novel anti-androgens represent a major advancement in treating advanced prostate cancer.
- Early data suggests darolutamide also shows promise in the nmCRPC setting.
Conclusions:
- Recent FDA approvals of apalutamide and enzalutamide have transformed nmCRPC treatment paradigms.
- These novel anti-androgens offer improved outcomes, particularly in delaying metastasis.
- Careful consideration of their benefits and challenges is crucial for optimal patient management.
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