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Updated: Jan 27, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
A visible-light-induced cascade reaction of etherification/C-C cyclization: efficient synthesis of
Wanyong Fu1, Aixia Yu, Hongshuo Jiang
1School of Chemistry and Materials Science, Heilongjiang University, Harbin, Heilongjiang 150080, PR China.
Abstract:
A visible-light-induced palladium-catalyzed cascade reaction was developed by etherification/C-C coupling cyclization of α-bromoacetophenones with phenols. A series of dibenzo[b,d]oxepin-7(6H)-one derivatives were efficiently synthesized by using this method in good yields. Furthermore, this method was applied to the synthesis of protosappanin A. The protocol has advantages such as simple reaction conditions, wide range of substrates and high reaction efficiency.
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