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Chronic Pharyngitis01:23

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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
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Osteitis in Chronic Rhinosinusitis.

Kornkiat Snidvongs1,2, Raymond Sacks3,4, Richard J Harvey3,5

  • 1Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drkornkiat@yahoo.com.

Current Allergy and Asthma Reports
|March 16, 2019
PubMed
Summary
This summary is machine-generated.

Osteitis, a common factor in chronic rhinosinusitis (CRS), involves bone remodeling. Its exact cause and link to patient outcomes in CRS remain unclear, despite associations with nasal polyps.

Keywords:
Computed tomographyEndoscopic sinus surgeryHistopathologyNasal polypsOsteitisRhinosinusitis

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Area of Science:

  • Otorhinolaryngology
  • Pathology
  • Radiology

Background:

  • Osteitis is frequently observed in chronic rhinosinusitis (CRS), particularly in revision surgeries and severe cases indicated by higher Lund-Mackay scores.
  • The precise etiology and pathogenesis of osteitis in CRS are not fully understood, with current evidence being inconclusive.

Purpose of the Study:

  • To provide a comprehensive narrative review of osteitis in chronic rhinosinusitis (CRS) patients.
  • To explore the pathogenesis, epidemiology, and clinical and biological correlations of osteitis in CRS.

Main Methods:

  • This review synthesizes existing literature on osteitis in CRS.
  • It examines histopathological findings, associated factors, and imaging assessments.

Main Results:

  • Osteitis in primary CRS appears to be a process of neo-osteogenesis and bone remodeling, not solely inflammatory.
  • Associations have been noted with nasal polyps, tissue eosinophilia, periostin, and P-glycoprotein expression.
  • No clear association exists between osteitis and patient symptoms, quality of life, or long-term surgical outcomes.

Conclusions:

  • Osteitis in CRS is likely an outcome of bone remodeling, especially in non-surgically treated patients.
  • Further research is needed to clarify the pathogenesis and clinical implications of osteitis in CRS.
  • Standardized CT grading for osteitis severity requires further development and validation.