Related Experiment Video
Updated: Jan 27, 2026
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
632
[Update on Diabetic Kidney Disease 2018].
Reto Martin Venzin1, Thomas Fehr1
11 Kantonsspital Graubünden, Departement Innere Medizin.
Therapeutische Umschau. Revue Therapeutique
|March 19, 2019
Summary
New SGLT-2 inhibitor therapies for diabetic kidney disease enhance glucose excretion, improving glycemic control and renal outcomes by reducing hyperfiltration. These benefits are currently confirmed in type 2 diabetes patients.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetic kidney disease (DKD) is a major complication of diabetes mellitus.
- Historical descriptions of diabetes mellitus noted
- sweet honey urine
- linked to hyperglycemia.
- Glomerular hyperfiltration is a key pathophysiological mechanism in DKD.
Purpose of the Study:
- To review the therapeutic update on diabetic kidney disease.
- To highlight the role of SGLT-2 inhibitors in managing DKD.
- To explore the potential of SGLT-2 inhibitors in non-diabetic kidney diseases with hyperfiltration.
Main Methods:
- Review of current literature on diabetic kidney disease and SGLT-2 inhibitors.
- Analysis of the mechanism of action of SGLT-2 inhibitors.
- Discussion of clinical trial data regarding SGLT-2 inhibitors in type 2 diabetes.
Main Results:
- SGLT-2 inhibitors enhance glucosuria, aligning with historical "sweet urine" observations.
- These inhibitors improve glycemic control and reduce glomerular hyperfiltration in type 2 diabetic patients.
- Positive renal outcomes have been demonstrated in type 2 diabetic patients treated with SGLT-2 inhibitors.
Conclusions:
- SGLT-2 inhibitors represent a novel and effective therapy for diabetic kidney disease in type 2 diabetes.
- The reduction of glomerular hyperfiltration is a key mechanism for renal protection.
- Further research is warranted to investigate the efficacy of SGLT-2 inhibitors in other kidney diseases characterized by hyperfiltration.
More Related Videos
07:01Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
Published on: May 10, 2022
1.9K
06:46A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
3.2K
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
697
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
697
01:24Chronic Kidney Disease II: Clinical Manifestations
613
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
613
01:28Chronic Kidney Disease III: Interprofessional Care
387
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
387
01:18Chronic Kidney Disease IV: Nursing Management
363
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
363
01:45Kidney Structure
75.1K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.1K
01:20Pathophysiology of Diabetes
3.5K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.5K