Related Experiment Video
Updated: Jan 27, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
A perspective on magnetic core-shell carriers for responsive and targeted drug delivery systems
Kholoud E Albinali1, Moustafa M Zagho1, Yonghui Deng2
1Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar, aelzatahry@qu.edu.qa.
Magnetic core-shell nanocarriers offer localized cancer treatment with tunable drug release. These advanced materials, utilizing iron oxide cores and diverse shells, show promise for targeted therapies.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Magnetic nanoparticles (MNPs) are gaining attention for their unique properties, including stability and localized treatment capabilities.
- MNPs can be functionalized to respond to specific triggers like pH, heat, or enzymes, enhancing their therapeutic potential.
- Current research emphasizes the application of these nanocarriers in cancer therapies.
Purpose of the Study:
- To review magnetic core-shell nanocarriers for drug delivery.
- To discuss the properties and applications of these nanocarriers in cancer treatment.
- To categorize different types of magnetic core-shell drug carriers.
Main Methods:
- Review of existing literature on magnetic core-shell nanocarriers.
- Analysis of core materials (Fe2O3, Fe3O4) and shell materials (e.g., PLGA, silica, lipids).
- Evaluation of magnetization properties, toxicity, and drug uptake/release efficacy.
Main Results:
- Various magnetic core-shell nanocarriers based on iron oxides with diverse shells (PLGA, PVP, chitosan, silica, calcium silicate, metal, lipids) were identified.
- These nanocarriers exhibit tunable properties for controlled drug delivery.
- Demonstrated potential for localized cancer treatment and targeted drug release.
Conclusions:
- Magnetic core-shell nanocarriers represent a promising platform for advanced cancer therapy.
- Their tailored physicochemical properties allow for targeted drug delivery and localized treatment.
- Further research into their efficacy and safety is warranted for clinical translation.
More Related Videos
10:16Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
08:47Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
Published on: September 28, 2022
Related Concept Videos
Electron Carriers
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
The Nucleosome Core Particle
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
Drug Delivery: Enteral Route
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...