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Updated: Jan 27, 2026

Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica
Zai-Qin Zheng, Wen-Jun Wei, Junmin Zhang
1College of Pharmaceutical Science , Zhejiang University of Technology , Hangzhou 310014 , China.
Abstract:
Heliaquanoid A (1), the first exo-2,4-linked Diels-Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B-E (2-5), four new 2,4-linked Diels-Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by NMR spectroscopy, a modified Mosher's method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively.
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