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Related Concept Videos

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
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Deformation in a Circular Shaft01:10

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One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
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Alternative RNA Splicing02:18

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Functional Brain Systems: Limbic System01:15

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The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
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Related Experiment Video

Updated: Jan 27, 2026

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Circular RNA expression and function in the brain.

Shobana Sekar1, Winnie S Liang1

  • 1Translational Genomics Research Institute, Phoenix, AZ, USA.

Non-Coding RNA Research
|March 21, 2019
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are increasingly understood for their roles in gene regulation and as potential biomarkers. Research highlights their extensive influence on brain function and neurological diseases, offering new therapeutic avenues.

Keywords:
BrainNeurological diseaseNon-coding RNAPSD, post-synaptic densityTranscriptional regulationcircRNAmicroRNA

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Last Updated: Jan 27, 2026

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are a class of non-coding RNAs with emerging roles in gene regulation.
  • Recent research has significantly advanced the understanding of circRNA expression and function.

Purpose of the Study:

  • To review recent research on circRNA expression in the brain.
  • To describe proposed circRNA functions, including microRNA sequestration and protein regulation.
  • To evaluate the role of circRNAs in neurological diseases and their potential as biomarkers.

Main Methods:

  • Literature review of studies on circRNA expression and function in the brain.
  • Analysis of evidence for circRNA roles in transcriptional regulation.
  • Evaluation of circRNAs as biomarkers for neurological conditions.

Main Results:

  • circRNAs exhibit diverse functions, including microRNA sponging and protein interaction.
  • Evidence suggests circRNAs can regulate gene transcription.
  • circRNAs are implicated in various neurological pathways and diseases.

Conclusions:

  • circRNAs play a significant role in brain function and neurobiology.
  • circRNAs hold potential as biomarkers for neurological diseases.
  • Further understanding of circRNAs may lead to novel therapeutic strategies for brain disorders.