Related Experiment Video
Updated: Jan 27, 2026

11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.5K
Clearance of psoriasis after ischemic stroke
Erica B Lee1, Kelly A Reynolds2, Deeti J Pithadia3
1John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Cutis
|March 21, 2019
Summary
The nervous system influences psoriasis. A patient with psoriasis saw complete remission after an ischemic stroke, suggesting a link between neurologic events and psoriasis.
Area of Science:
- Dermatology
- Neuroscience
- Immunology
Background:
- The nervous system's role in psoriasis pathogenesis is not fully understood.
- Clinical observations suggest a connection, with psoriasis sparing neurologic disease areas and improving with nerve damage.
- Neuropeptides like substance P (SP) are implicated in psoriasis development.
Observation:
- A case study of a patient with psoriasis is presented.
- The patient experienced a complete remission of psoriasis symptoms.
Findings:
- The psoriasis remission occurred following an ischemic stroke.
- This suggests a potential causal or significant correlative link between acute neurologic events and psoriasis resolution.
Implications:
- Neurologic events may influence or even resolve psoriasis.
- Further research into neuro-immune interactions in psoriasis is warranted.
- This case opens new avenues for understanding psoriasis triggers and potential therapeutic targets.
Related Concept Videos
Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance
507
Hepatic clearance refers to the volume of blood cleared of a drug by the liver per unit of time. It plays a crucial role in drug metabolism and elimination. While hepatic clearance is commonly estimated by subtracting renal clearance from total body clearance, other pathways, such as pulmonary or biliary clearance, may also contribute. However, these pathways are generally less significant than hepatic and renal clearance.
Most drugs undergo restrictive clearance, which is proportional to the...
Most drugs undergo restrictive clearance, which is proportional to the...
507
Renal Clearance
2.6K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.6K
Drug Clearance: Overview
405
Drug elimination refers to drug removal from the body, either through urine or bile, by the kidneys or liver, respectively. A pharmacokinetic parameter, drug clearance, measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the drug's concentration in plasma.
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination, including...
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination, including...
405
Clearance Models: Noncompartmental Models
258
Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
258
Renal Drug Clearance: Overview
725
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
725
Drug Elimination: The Concept of Clearance
3.9K
Drug elimination refers to removing drugs from the body, either through urine by the kidneys or through bile by the liver. Drug clearance is a pharmacokinetic parameter that measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the plasma concentration of the drug.
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination,...
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination,...
3.9K

