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Characterization of myophage AM24 infecting Acinetobacter baumannii of the K9 capsular type

Anastasia V Popova1,2,3, Mikhail M Shneider4,5, Vera P Myakinina6

  • 1Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia. popova_av@mipt.ru.

Archives of Virology
|March 22, 2019
PubMed

Insights

This study characterizes bacteriophage AM24, a virulent virus targeting multidrug-resistant Acinetobacter baumannii. Its genome analysis reveals key genes for bacterial cell lysis and infection, enhancing our understanding of phage diversity.

Area of Science:

  • Microbiology
  • Virology
  • Genomics

Background:

  • Acinetobacter baumannii is a multidrug-resistant pathogen.
  • Bacteriophages offer potential therapeutic alternatives.
  • Understanding phage-host interactions is crucial for phage therapy development.

Purpose of the Study:

  • To investigate the biological properties and genomic organization of bacteriophage AM24.
  • To determine the host range and infection mechanism of AM24.
  • To contribute to the knowledge of Acinetobacter baumannii phages.

Main Methods:

  • Transmission electron microscopy for phage morphology.
  • Genome sequencing and analysis of bacteriophage AM24.
  • Bioinformatic analysis to identify open reading frames and predict gene functions.

Main Results:

  • Bacteriophage AM24 belongs to the Myoviridae family.
  • The phage has a linear double-stranded DNA genome of 97,177 bp with 167 open reading frames.
  • The tailspike depolymerase gene is located outside the structural module, upstream of DNA packaging genes.

Conclusions:

  • Bacteriophage AM24 is a virulent phage targeting specific Acinetobacter baumannii strains.
  • Genomic analysis provides insights into phage replication, assembly, and lysis mechanisms.
  • The characterization of AM24 expands our understanding of phage diversity against Acinetobacter baumannii.

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