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Related Experiment Videos

Diazepam-induced decrease in histamine turnover in mouse brain.

R Oishi, M Nishibori, Y Itoh

    European Journal of Pharmacology
    |May 27, 1986
    PubMed
    Summary

    Diazepam, a common benzodiazepine, was found to decrease brain histamine turnover in mice at higher doses. This effect is linked to the benzodiazepine-gamma-aminobutyric acid (GABA) receptor complex.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Histamine plays a crucial role in various brain functions.
    • Benzodiazepines are widely used anxiolytic and sedative medications.
    • The interaction between benzodiazepines and histamine in the brain is not fully understood.

    Purpose of the Study:

    • To investigate the effect of diazepam on histamine turnover in the mouse brain.
    • To explore the potential involvement of the benzodiazepine-GABA receptor complex in this interaction.

    Main Methods:

    • Mice were administered varying doses of diazepam.
    • Histamine and tele-methylhistamine levels were measured.
    • Histamine turnover was estimated using pargyline treatment.
    • Effects of other benzodiazepines and muscimol were assessed.

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  • Benzodiazepine antagonist Ro 15-1788 was used to block effects.

    • Main Results:

    • Diazepam (over 5 mg/kg) significantly decreased brain histamine turnover.
    • Other benzodiazepines also reduced histamine turnover at high doses.
    • Diazepam potentiated the inhibitory effect of muscimol on histamine turnover.
    • These effects were antagonized by Ro 15-1788.

    Conclusions:

    • Diazepam, at pharmacologically relevant doses, inhibits brain histamine turnover.
    • The findings suggest that diazepam exerts its effect on histamine turnover via the benzodiazepine-GABA receptor complex.