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Application of Drosophila Model Toward Understanding the Molecular Basis of Fragile X Syndrome
Ha Eun Kong1, Junghwa Lim1, Peng Jin2
1Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Abstract:
Drosophila melanogaster is an ideal model to study Fragile X syndrome (FXS) as it presents us with a toolbox to identify genetic modifiers and to investigate the molecular mechanisms of FXS. Here we describe some of the methods that have been used to study FXS, ranging from reverse genetic screening using the GAL4-UAS system, to mushroom body staining and courtship behavioral assays to examine the learning and memory deficits associated with FXS.
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