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Published on: February 27, 2016
Four-dimensional Flow MRI: Principles and Cardiovascular Applications
Arshid Azarine1, Philippe Garçon1, Audrey Stansal1
1From the Departments of Medical Imaging (A.A., N.C., G.A., S.S., V.M., M.Z.), Cardiology (P.G.), and Vascular Medicine (A.S.), Saint Joseph Hospital, 185 rue Raymond Losserand, 75014 Paris, France; and Department of Pediatric Cardiology, Necker Enfants Malades Hospital, Paris, France (D.S.).
Four-dimensional (4D) flow MRI, a cardiac MRI technique, offers detailed blood flow analysis for cardiovascular diseases. Advances enhance its clinical feasibility for diagnosing conditions like congenital heart disease and valve disorders.
Area of Science:
- Cardiovascular Imaging
- Medical Physics
- Biomedical Engineering
Background:
- In-plane phase-contrast (PC) MRI is standard for assessing heart and great vessel blood flow.
- Four-dimensional (4D) flow MRI, a 3D, time-resolved technique, enables comprehensive blood flow analysis.
Purpose of the Study:
- To review technical considerations and applications of 4D flow MRI in cardiovascular diseases.
- To highlight advancements improving 4D flow MRI's clinical utility.
Main Methods:
- Utilizes volumetric, isotropic, time-resolved cine sequences with three-directional velocity encoding.
- Incorporates retrospective multiplanar navigation for flexible flow quantification.
- Employs advanced visualization tools like streamlines and velocity vectors.
Main Results:
- Recent technical and big-data processing advances shorten imaging times and improve feasibility.
- 4D flow MRI provides accurate quantification of various flow parameters (e.g., forward flow, regurgitation fraction, wall shear stress).
- Enables detailed analysis of complex blood flow patterns.
Conclusions:
- 4D flow MRI is a powerful tool for analyzing cardiovascular disorders.
- Its applications are expanding across congenital heart disease, valvular disease, aortic disease, and pulmonary hypertension.
- Technical optimization and advanced processing are key to its growing clinical importance.
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