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Is HIF1-a deregulated in malignant salivary neoplasms?
Claudio Marcelo Cardoso1, Sabrina Ferreira de Jesus2, Marcela Gonçalves de Souza2
1Department of Medicine, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil; Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil.
Background:
There is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs).
Objective:
The current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms.
Patients And Methods:
The current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR.
Results:
No differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups.
Conclusion:
The angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.
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