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Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
Published on: October 13, 2017
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Cytokine Profiling of Subclinical Tick-Borne Infections in Humans.
G A Danchinova1, M A Khasnatinov2, N A Lyapunova2
1Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia. dan-chin@yandex.ru.
Bulletin of Experimental Biology and Medicine
|March 24, 2019
Summary
Early detection of tick-borne infections is possible by monitoring immune responses. Specific cytokine profiles in blood plasma can indicate viral or bacterial infections within 2-5 days post-bite, aiding in timely diagnosis and prevention.
Area of Science:
- * Immunology and infectious diseases.
- * Human health and public safety.
Background:
- * Tick-borne infections pose a significant global health risk.
- * Early detection is crucial for managing these diseases, often before symptoms appear.
Purpose of the Study:
- * To investigate early immune response indicators for tick-borne infections.
- * To differentiate between viral and bacterial tick-borne pathogen responses.
Main Methods:
- * Analysis of immune response markers, including cytokines and superoxide dismutase.
- * Monitoring changes in blood plasma concentrations post-tick bite.
Main Results:
- * Distinct cytokine profiles observed for viral (increased IL-1α, IL-8, IL-10, IL-17A, IFNγ; increased superoxide dismutase) versus bacterial (increased IL-1α, IL-8, IFNα; suppressed superoxide dismutase, IL-1Ra, IL-17A) infections.
- * Immune response and detectable cytokine changes occur rapidly, within 2-5 days after a tick bite.
- * A slight decrease in Interleukin-1 receptor antagonist (IL-1Ra) concentration noted in viral infections.
Conclusions:
- * Early immune response profiling can serve as an indicator for tick-borne infections.
- * Cytokine analysis offers a potential method for rapid, early diagnosis.
- * Findings support the development of novel diagnostic and preventive strategies for tick-borne diseases.
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