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Role of Vitamins in Maintaining Bone Health01:25

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Bone function, dysfunction and its role in diseases including critical illness.

Nan Su1, Jing Yang1, Yangli Xie1

  • 1Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

International Journal of Biological Sciences
|March 26, 2019
PubMed
Summary
This summary is machine-generated.

Critical illness causes bone dysfunction, characterized by rapid bone loss and impaired skeletal functions. Enhancing bone function may improve outcomes in critical illness and other diseases.

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Area of Science:

  • Skeletal biology and critical care medicine.

Background:

  • The skeleton performs conventional functions (support, movement, protection) and extraskeletal functions vital for whole-body homeostasis.
  • Bone-derived factors (BDFs) regulate these functions. Bone dysfunction occurs when skeletal disorders impair these functions, impacting other organs.

Purpose of the Study:

  • To propose and define bone dysfunction in the context of critical illness.
  • To explore the relationship between skeletal status and critical illness severity/prognosis.

Main Methods:

  • The study defines bone function and bone dysfunction based on existing literature and pathophysiological principles.
  • It reviews the skeletal changes observed in critical illness, including bone loss and impaired osteoblast function.

Main Results:

  • Critical illness is characterized by rapid bone loss due to increased bone resorption and reduced osteoblast activity.
  • Skeletal dysfunction in critical illness correlates with disease severity and patient prognosis.

Conclusions:

  • Bone dysfunction is a significant component of critical illness.
  • Therapeutic strategies aimed at enhancing bone function, such as inhibiting osteoclasts or promoting osteoblasts, show potential for improving critical illness outcomes.