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Updated: Jan 27, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Selective Syntheses of Z-Alkenes via Photocatalyzed Decarboxylative Coupling of N-Hydroxyphthalimide Esters with
Guo-Li Dai1, Shu-Zhen Lai1, Zhuangzhu Luo2
1Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering , Central South University , Changsha 410083 , China.
Abstract:
A novel, efficient Z-alkene synthesis via photocatalyzed decarboxylative couplings between terminal aryl alkynes and alkyl N-hydroxyphthalimide (NHPI) esters, which are derived from aliphatic carboxylic acids, is described. A wide range of primary, secondary, and tertiary carboxylates as well as α-amino acid and α-oxyacid-derived esters were employed as suitable substrates. The mild reaction conditions, broad substrate scope, functional group tolerance, and operational simplicity make this decarboxylative coupling reaction a valuable method in organic syntheses.
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Nomenclature of Alkenes
As per the IUPAC rules, the longest carbon chain containing the maximum number of double bonds is identified as the parent chain and is numbered such that the doubly bonded carbon atoms receive the lowest possible numbers. The location of the double bond is indicated by the number of its first carbon atom. In branched...

