Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Flow01:29

Blood Flow

75.7K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
75.7K
Composition of Blood01:22

Composition of Blood

11.7K
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
11.7K
Blood Types02:20

Blood Types

22.6K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
22.6K
The ABO Blood Group01:12

The ABO Blood Group

4.8K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
4.8K
Rh Blood Group01:19

Rh Blood Group

2.9K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.9K
Blood Typing01:10

Blood Typing

2.5K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survey of national and regional rare donor programmes regarding Immunoglobulin A deficiency.

Vox sanguinis·2026
Same author

Rhesus blood group haplotype determination by nanopore sequencing and adaptive sampling enables the precise determination of complex allele combinations that could not be accurately determined by standard methods.

Transfusion·2026
Same author

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems.

Vox sanguinis·2025
Same author

Patient characteristics and clinical determinants of outpatient red cell transfusions.

Transfusion·2025
Same author

Cellular expression of PD-1, PD-L1 and CTLA-4 in patients with JAK2<sup>V617F</sup> mutated myeloproliferative disorders.

Clinical chemistry and laboratory medicine·2025
Same author

Expression of sPD-L1 levels in an ex vivo liver perfusion model.

Clinical and experimental immunology·2024

Related Experiment Video

Updated: Jan 27, 2026

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool
10:15

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool

Published on: May 9, 2025

685

An update on the CD59 blood group system.

Christof Weinstock1, Markus Anliker2, Inge von Zabern3

  • 1Head of the Immunohematology Laboratory, Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Service.

Immunohematology
|March 26, 2019
PubMed
Summary

CD59 deficiency, a rare condition affecting complement inhibition, now has 14 reported patients, all severely ill. Research identifies new variant alleles, enhancing understanding of this crucial blood group system.

More Related Videos

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.6K
Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

875

Related Experiment Videos

Last Updated: Jan 27, 2026

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool
10:15

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool

Published on: May 9, 2025

685
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.6K
Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

875

Area of Science:

  • Immunology
  • Hematology
  • Genetics

Background:

  • The CD59 protein is a critical regulator of the complement system, preventing cell damage.
  • CD59 deficiency has been associated with severe clinical manifestations.
  • The CD59 blood group system (ISBT 35) previously comprised a single antigen.

Purpose of the Study:

  • To update the understanding of the CD59 blood group system.
  • To report on newly identified CD59 variant alleles and associated patient cases.
  • To characterize the expression of a novel CD59 variant.

Main Methods:

  • Literature review and case series analysis.
  • Genetic analysis to identify variant alleles.
  • Flow cytometry to assess protein expression on red blood cells.

Main Results:

  • The number of reported patients with CD59 deficiency has increased from 10 to 14.
  • All 14 patients presented with severe illness.
  • A new variant allele of CD59 was identified in heterozygosity, expressed on red blood cells.

Conclusions:

  • CD59 deficiency is consistently linked to severe disease.
  • The identification of new alleles expands the known genetic landscape of CD59.
  • Despite new alleles, the CD59 blood group system antigenically remains monomorphic.