Related Experiment Video
Updated: Jan 27, 2026
09:02
Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
Published on: October 14, 2021
5.6K
Physiological Regulation of Innate Lymphoid Cells
Nicolas Jacquelot1,2, Kylie Luong1, Cyril Seillet1,2
1Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Frontiers in Immunology
|March 28, 2019
Summary
Innate lymphoid cells (ILCs) maintain tissue health and immunity by sensing signals from pathogens and the body. Understanding how physiological signals regulate ILCs is key to their protective and pathological roles.
Area of Science:
- Immunology
- Cell Biology
- Physiology
Background:
- Innate lymphoid cells (ILCs) are crucial for immune protection and tissue homeostasis at barrier surfaces.
- ILCs possess diverse functions, impacting disease outcomes beneficially or detrimentally.
- ILCs integrate various signals to perform their roles effectively.
Purpose of the Study:
- To review recent advances in understanding the physiological regulation of ILCs.
- To explore how ILCs sense and integrate host-derived signals.
- To elucidate the consequences of ILC regulation on tissue homeostasis.
Main Methods:
- Literature review of recent studies on ILC regulation.
- Analysis of ILC sensitivity to pathogen-derived and host-derived stimuli.
- Examination of the cross-talk between ILCs and physiological systems.
Main Results:
- ILCs are sensitive to pathogen stimuli, neuropeptides, hormones, and metabolites.
- A complex cross-talk exists between ILCs and the nervous, endocrine, digestive, and reproductive systems.
- Physiological regulation significantly influences ILC functions.
Conclusions:
- Understanding ILC regulation by physiological signals is vital for comprehending their roles in health and disease.
- This knowledge advances our understanding of tissue homeostasis maintenance.
- Further research into ILC-physiology interactions holds therapeutic potential.
Related Concept Videos
01:18Lymphoid Cells and Tissues
3.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.0K
01:28Cells of the Innate Immune Response
8.9K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.9K
01:28pH Regulation in Cells
7.6K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.6K
01:15Secondary Lymphoid Organs
9.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.2K
01:16Primary Lymphoid Organs
15.0K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
15.0K
01:46Epigenetic Regulation
33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K