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Updated: Jan 27, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers
Raul Martin-Montero1,2, Veera Reddy Yatham1, Hongfei Yin1
1Institute of Chemical Research of Catalonia (ICIQ) , The Barcelona Institute of Science and Technology, Av. Països Catalans 16 , 43007 Tarragona , Spain.
Abstract:
A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.
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