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Updated: Jan 27, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
Published on: December 5, 2018
Mechanisms associated with biogenesis of exosomes in cancer
Kathleen M McAndrews1, Raghu Kalluri2
1Department of Cancer Biology, Metastasis Research Center, University of Texas, MD Anderson Cancer Center, Unit 1906, 1881 East Road, Houston, TX, 77054, USA. kmmcandrews@mdanderson.org.
Abstract:
Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in cancer.
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