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Updated: Jan 27, 2026

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Rare Event Detection Using Error-corrected DNA and RNA Sequencing
Published on: August 3, 2018
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Rare event simulation for steady-state probabilities via recurrency cycles.
Krzysztof Bisewski1, Daan Crommelin1, Michel Mandjes2
1Centrum Wiskunde and Informatica, Science Park 123, 1098 XG Amsterdam, The Netherlands.
Chaos (Woodbury, N.Y.)
|April 1, 2019
Summary
We introduce Recurrent Multilevel Splitting (RMS), a novel algorithm for estimating rare event probabilities in Markov chains. RMS significantly enhances computational efficiency compared to traditional Monte Carlo methods.
Area of Science:
- Computational Mathematics
- Stochastic Processes
- Numerical Analysis
Background:
- Estimating rare event probabilities in continuous-state Markov chains is computationally challenging.
- Existing methods often lack efficiency for complex systems.
- Markov chains are fundamental models in various scientific domains.
Purpose of the Study:
- To develop a new, efficient algorithm for rare event probability estimation.
- To leverage the recurrent structure of Markov chains for improved computation.
- To address limitations of existing computational methods.
Main Methods:
- Development of the Recurrent Multilevel Splitting (RMS) algorithm.
- Utilizing the underlying recurrent structure of Markov chains.
- Integration with the Multilevel Splitting (MS) technique.
- Application to discrete-time R^d-valued Markov chains.
Main Results:
- The proposed RMS algorithm demonstrates significant computational efficiency gains.
- RMS outperforms standard Monte Carlo methods by several orders of magnitude.
- Validation through extensive simulation experiments, including complex nonlinear stochastic models.
Conclusions:
- RMS offers a computationally efficient approach for rare event probability estimation.
- The algorithm's effectiveness is demonstrated on challenging stochastic models.
- RMS provides a valuable tool for analyzing complex systems in fields like climate modeling.
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