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Updated: Jan 27, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
Published on: August 3, 2018
Rare event simulation for steady-state probabilities via recurrency cycles
Krzysztof Bisewski1, Daan Crommelin1, Michel Mandjes2
1Centrum Wiskunde and Informatica, Science Park 123, 1098 XG Amsterdam, The Netherlands.
Abstract:
We develop a new algorithm for the estimation of rare event probabilities associated with the steady-state of a Markov stochastic process with continuous state space Rd and discrete time steps (i.e., a discrete-time Rd-valued Markov chain). The algorithm, which we coin Recurrent Multilevel Splitting (RMS), relies on the Markov chain's underlying recurrent structure, in combination with the Multilevel Splitting method. Extensive simulation experiments are performed, including experiments with a nonlinear stochastic model that has some characteristics of complex climate models. The numerical experiments show that RMS can boost the computational efficiency by several orders of magnitude compared to the Monte Carlo method.
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