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Related Experiment Video

Updated: Jan 27, 2026

Visualizing Hyporheic Flow Through Bedforms Using Dye Experiments and Simulation

Visualizing Hyporheic Flow Through Bedforms Using Dye Experiments and Simulation

Published on: November 18, 2015

Multiphase flow experiment and simulation for cells-on-a-chip devices.

Meihua Zhang¹, Amy Zheng², Zhongquan C Zheng¹

¹1 Department of Aerospace Engineering, The University of Kansas, Lawrence, KS, USA.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine

|April 2, 2019

Summary

This summary is machine-generated.

This study develops multiphase flow models for cells-on-a-chip devices, validating simulations with experiments. These models accurately predict cell deposition and concentration, aiding in the design of microfluidic cell culture systems.

Keywords:

Cells-on-a-chip device(s)cell deposition microfluidic chip particulate multiphase flow

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Area of Science:

Biomedical Engineering
Microfluidics
Computational Fluid Dynamics

Background:

Microfluidic devices, or cells-on-a-chip, offer controlled environments mimicking human organ networks.
Accurate simulation of fluid dynamics is crucial for optimizing these devices.

Purpose of the Study:

To develop and validate multiphase flow models for simulating fluid dynamics and cell behavior in microfluidic cell-culture devices.
To investigate factors influencing cell deposition and concentration within these systems.

Main Methods:

Fabrication of 3D microfluidic chips using standard soft lithography.
Experimental validation of numerical simulations for particle velocity.
Development and application of multiphase flow models to study cell deposition and concentration.

Main Results:

Experimental and simulation results showed good agreement for particle velocity, validating the numerical approach.
The study investigated the impact of flow shear, gravity, inlet velocity, and cell injection number on cell concentration.
Comparisons between different cells-on-a-chip designs were addressed.

Conclusions:

Multiphase flow models are effective for simulating cell particle deposition and concentration in microfluidic devices.
The validated models provide a promising tool for the rational design of cells-on-a-chip systems.