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Updated: Jan 27, 2026
03:37
Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
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Predictors of Endophthalmitis after Intravitreal Injection: A Multivariable Analysis Based on Injection Protocol and
Maxwell S Stem1, Prethy Rao1, Ivan J Lee2
1Associated Retinal Consultants, PC, William Beaumont Hospital, Royal Oak, Michigan.
Ophthalmology. Retina
|April 2, 2019
Summary
The incidence of endophthalmitis after anti-VEGF injections is low. However, using lidocaine jelly or Tetravisc may increase the risk of this serious complication.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Anti-vascular endothelial growth factor (VEGF) therapy is a common treatment for various retinal diseases.
- Endophthalmitis is a rare but severe complication that can occur after intravitreal injections.
Purpose of the Study:
- To determine the incidence of endophthalmitis following anti-VEGF injections.
- To identify potential risk factors associated with endophthalmitis after these injections.
Main Methods:
- A retrospective, single-center cohort study was conducted.
- Data from 154,198 anti-VEGF injections administered between January 2014 and March 2017 were analyzed.
- Billing codes and medical records were reviewed to identify endophthalmitis cases and analyze injection techniques.
Main Results:
- The overall incidence of endophthalmitis was 0.038% (1 in 2659 injections).
- Use of 2% lidocaine jelly (OR, 11.28) and 0.5% Tetravisc (OR, 3.95) were identified as independent risk factors for endophthalmitis.
- Several other factors, including lid speculum use and povidone-iodine strength, were not significant predictors.
Conclusions:
- The incidence of endophthalmitis after anti-VEGF injections is low.
- The use of lidocaine jelly or Tetravisc may elevate the risk of endophthalmitis post-injection.
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