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Published on: March 27, 2014
General, Practical and Selective Oxidation Protocol for CF₃S into CF₃S(O) Group
Liubov V Sokolenko1, Raisa K Orlova2, Andrey A Filatov3
1Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans'ka Str. 5, 02094 Kyiv, Ukraine. sokolenko.liubov@gmail.com.
Abstract:
A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H₂O₂ aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales.
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