[Update on primary brain tumours]

Update on primary brain tumours Abstract. Primary brain tumors comprise a heterogeneous group of clinically, histologically and molecularly distinct entities. The World Health Organisation (WHO) revised the classification of tumors of the central nervous system in 2016 and defined molecular markers for the diagnosis of some entities. For example, co-deletion of chromosome arms 1 p and 19 q now defines oligodendrogliomas, irrespective of their histopathological appearance. Astrocytomas are segregated into such with mutated isocitrate dehydrogenase (IDH) and better prognosis, and such with IDH wildtype, which also comprise the vast majority of glioblastomas, the most common and prognostically least favorable malignant primary brain tumors in adults. Here, we provide an overview of the most common primary brain tumor entities and implications of the 2016 classification for the clinical management. Moreover, we provide an outlook on novel therapeutic approaches.