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Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study
Diana Lazarevic1, Egle Ramelyte1, Reinhard Dummer1
1Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Dermatology (Basel, Switzerland)
|April 3, 2019
Summary
Radiotherapy (RT) is an effective treatment for periocular skin tumors, offering good therapeutic responses with few adverse events. This study evaluated RT safety and efficacy for various skin malignancies around the eye.
Area of Science:
- Oncology
- Dermatology
- Radiation Oncology
Background:
- Periocular skin malignancies pose significant functional and cosmetic challenges.
- Effective treatment options for these tumors are crucial.
Purpose of the Study:
- To assess the safety and efficacy of radiotherapy (RT) for treating periocular skin tumors.
- To evaluate recurrence rates and adverse events associated with RT.
Main Methods:
- Retrospective review of patients treated with grenz or soft X-rays for periocular tumors (2009-2014).
- Included diagnoses: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, lentigo maligna (LM), lymphoma, Kaposi's sarcoma.
- Analysis of 159 lesions in 145 patients.
Main Results:
- Overall recurrence rates varied by diagnosis: actinic keratosis/Bowen's disease (27%), melanoma (17%), LM (15%), SCC (11%), BCC (10%).
- 45% of recurrences happened within 12 months, with a median recurrence time of 13 months.
- RT demonstrated a good therapeutic response with minimal adverse events.
Conclusions:
- Radiotherapy is a viable treatment option for periocular cutaneous malignancies.
- RT offers a favorable balance of efficacy and safety for these challenging tumors.
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