[Posterior Quadrantectomy for Infant with Refractory Epilepsy:A Case Report]

Area of Science:

• Neurology
• Pediatric Epilepsy Surgery
• Developmental Neuroscience

Background:

• Linear nevus sebaceous syndrome can be associated with intractable epilepsy.
• Cortical dysplasia is a common cause of refractory seizures in children.
• Early diagnosis and intervention are crucial for managing pediatric epilepsy.

Observation:

• An 11-month-old girl with linear nevus sebaceous syndrome presented with intractable epileptic spasms and developmental delay.
• Epileptic foci were identified in the right temporal, parietal, and occipital lobes via EEG, MRI, and SPECT.
• Antiepileptic drug treatment failed to control the seizures.

Findings:

• Posterior quadrantectomy (PQ) was performed due to the extensive nature of the cortical dysplasia.
• The surgical intervention resulted in complete resolution of epileptic spasms.
• Post-operative improvement in developmental delay was observed.

Implications:

• Posterior quadrantectomy is a viable surgical option for drug-resistant epilepsy with extensive foci in the posterior brain regions.
• Early surgical intervention can lead to seizure control and facilitate improved neurodevelopmental outcomes.
• This case highlights the importance of considering surgical management for severe pediatric epilepsy syndromes.