Related Experiment Video

Updated: Jan 26, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

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[Posterior Quadrantectomy for Infant with Refractory Epilepsy:A Case Report]

Taiki Saito1, Makoto Oishi, Masafumi Fukuda

  • 1Department of Neurosurgery, Brain Research Institute, Niigata University.

No Shinkei Geka. Neurological Surgery
|April 4, 2019
PubMed

Insights

Posterior quadrantectomy effectively treated intractable epilepsy in a child with linear nevus sebaceous syndrome. This surgical intervention resolved seizures and improved developmental delay, offering a promising solution for drug-resistant cases.

Area of Science:

  • Neurology
  • Pediatric Epilepsy Surgery
  • Developmental Neuroscience

Background:

  • Linear nevus sebaceous syndrome can be associated with intractable epilepsy.
  • Cortical dysplasia is a common cause of refractory seizures in children.
  • Early diagnosis and intervention are crucial for managing pediatric epilepsy.

Observation:

  • An 11-month-old girl with linear nevus sebaceous syndrome presented with intractable epileptic spasms and developmental delay.
  • Epileptic foci were identified in the right temporal, parietal, and occipital lobes via EEG, MRI, and SPECT.
  • Antiepileptic drug treatment failed to control the seizures.

Findings:

  • Posterior quadrantectomy (PQ) was performed due to the extensive nature of the cortical dysplasia.
  • The surgical intervention resulted in complete resolution of epileptic spasms.
  • Post-operative improvement in developmental delay was observed.

Implications:

  • Posterior quadrantectomy is a viable surgical option for drug-resistant epilepsy with extensive foci in the posterior brain regions.
  • Early surgical intervention can lead to seizure control and facilitate improved neurodevelopmental outcomes.
  • This case highlights the importance of considering surgical management for severe pediatric epilepsy syndromes.

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