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Correction to: Laxative effect of repeated Daiokanzoto is attributable to decrease in aquaporin-3 expression in the
Risako Kon1, Miho Yamamura2, Yukari Matsunaga3
1Global Research Center for Innovative Life Science, Hoshi University, Tokyo, Japan.
Journal of Natural Medicines
|April 4, 2019
Summary
Repeated use of Daiokanzoto laxative reduces aquaporin-3 expression in the colon. This molecular change in the large intestine contributes to the observed laxative effect, offering insight into its mechanism.
Area of Science:
- Gastroenterology
- Pharmacology
- Molecular Biology
Context:
- The study investigates the pharmacological mechanism of Daiokanzoto, a traditional Japanese herbal medicine.
- Constipation is a common condition, and understanding the action of laxatives is crucial for effective treatment.
Purpose:
- To elucidate the molecular mechanisms underlying the laxative effect of repeated Daiokanzoto administration.
- To investigate the role of aquaporin-3 in the colon in response to Daiokanzoto.
Summary:
- Repeated administration of Daiokanzoto leads to a significant decrease in aquaporin-3 expression in the colon.
- Aquaporin-3, a water channel protein, plays a role in water absorption in the colon.
- Reduced aquaporin-3 expression likely impairs water absorption, contributing to the laxative effect.
Impact:
- Provides a molecular explanation for the efficacy of Daiokanzoto as a laxative.
- Highlights aquaporin-3 as a potential therapeutic target for managing constipation.
- Contributes to the scientific understanding of herbal medicine's action on the gastrointestinal tract.
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