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Updated: Jan 26, 2026

Isolation and Characterization of RNA-Containing Exosomes
Published on: January 9, 2012
Oncogenic effects of exosomes in γ-herpesvirus-associated neoplasms
Jiayu Zheng1,2, Yiwan Shi2, Zhenyu Feng2
1Microbiology and Immunology Department, Basic Medical School, Guangdong Medical University, Dongguan, Guangdong, China.
Abstract:
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus-associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve extensive infections and even oncogenesis. In this review, we discuss the oncogenic biomolecules present in exosomes derived from KSHV- and EBV-infected cells. Moreover, oncogenesis via exosomal biomolecules mainly occurs through three processes, including regulation of downstream signals, promotion of immune dysfunction and transformation of cells. Also, the exosomes may provide diagnostic markers and therapeutic targets specific for KSHV- and EBV-associated malignancies.
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