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Updated: Jan 26, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.6K
Clear Cell Primary Cutaneous Anaplastic Large Cell Lymphoma.
Shira Ronen1, Matan Rothschild2, Jose Ollague3
1Departments of Pathology, and.
The American Journal of Dermatopathology
|April 5, 2019
Summary
A rare primary cutaneous anaplastic large cell lymphoma presented with a clear cell appearance. This unusual morphology can mimic other tumors, highlighting the need for careful diagnosis.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare non-Hodgkin lymphoma.
- pcALCL typically presents as skin lesions, often on the extremities.
Observation:
- A case of pcALCL in a 38-year-old man exhibited a striking clear cell morphology.
- The tumor presented as a large, ulcerated lesion on the thigh.
- Histopathological examination revealed large, pleomorphic tumor cells with abundant clear cytoplasm.
Findings:
- Immunohistochemistry confirmed tumor cell positivity for CD3, CD4, CD30, and CD45RO.
- The cells were negative for cytokeratin, p63, S-100, ALK-1, PAX5, CD8, CD15, CD20, CD43, CD56, and Epstein-Barr virus.
- A high proliferation index (MIB-1) of approximately 40% was noted.
Implications:
- The clear cell appearance can lead to diagnostic confusion with other neoplasms, such as clear cell carcinoma or melanoma.
- Recognizing this unusual presentation of pcALCL is crucial for accurate diagnosis and appropriate treatment planning.
- This case underscores the importance of comprehensive immunohistochemical analysis in diagnosing cutaneous lymphomas.
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