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Updated: Jan 26, 2026
Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research
Published on: July 12, 2021
Synthesis of Benzophenones and in vitro Evaluation of Their Anticancer Potential in Breast and Prostate Cancer Cells
Lydia Saidi1, Djenisa H A Rocha2,3, Oualid Talhi2,4
1Laboratory of Applied Organic Chemistry, Faculty of Chemistry, Houari Boumediene University of Sciences and Technology, USTHB, BP 32, El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria.
Abstract:
Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single-crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC50 values ranging from 12.09 to 26.49 μm) and induced cell-cycle retardation only on prostate cancer cells, which suggested that it might exert cell-type-specific effects.
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