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Updated: Jan 26, 2026
04:53
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
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PHOTODYNAMIC THERAPY FOR EXTRAFOVEOLAR CHOROIDAL OSTEOMA
Mehdi Mazloumi1, Lauren A Dalvin1,2, David Ancona-Lezama1
1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and.
Retina (Philadelphia, Pa.)
|April 6, 2019
Summary
Photodynamic therapy (PDT) effectively manages extrafoveolar choroidal osteoma by regressing tumors and preventing foveal involvement. This treatment preserves visual acuity in most patients with this rare bone tumor of the eye.
Area of Science:
- Ophthalmology
- Medical Imaging
- Oncology
Background:
- Choroidal osteoma is a rare, benign ossifying tumor of the choroid.
- Extrafoveolar choroidal osteoma poses a risk of visual impairment due to potential foveal encroachment.
Purpose of the Study:
- To assess the efficacy of photodynamic therapy (PDT) in treating extrafoveolar choroidal osteoma.
- To evaluate the impact of PDT on tumor regression and visual acuity.
Main Methods:
- Retrospective chart review of patients with extrafoveolar choroidal osteoma treated with standard-fluence PDT.
- Analysis of tumor regression, growth patterns, and visual acuity outcomes post-treatment.
Main Results:
- Nine eyes with extrafoveolar choroidal osteoma were treated with PDT.
- Mean visual acuity improved post-treatment (0.07 to 0.04 LogMAR).
- Tumor regression was observed in all treated areas (73% mean regression), with 8 of 9 cases showing controlled growth, preserving visual function.
Conclusions:
- Photodynamic therapy is a safe and effective treatment for extrafoveolar choroidal osteoma.
- PDT minimizes the risk of tumor progression towards the fovea.
- This therapeutic approach helps maintain or improve visual acuity in affected individuals.
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