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Updated: Jan 26, 2026

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation
Published on: August 20, 2019
Noninvasive Transcranial Magnetic Brain Stimulation in Stroke
Julio C Hernandez-Pavon1, Richard L Harvey2
1Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Brain Stimulation, Shirley Ryan AbilityLab, 355 East Erie Street, Chicago, IL 60611, USA.
Transcranial magnetic brain stimulation shows promise for treating stroke and related impairments. Future applications may involve tailored targets, biomarkers, and combined therapies for optimal patient outcomes.
Area of Science:
- Neuroscience
- Neurology
- Rehabilitation Medicine
Background:
- Stroke is a leading cause of long-term disability.
- Current treatments for stroke-related impairments have limitations.
- Transcranial magnetic brain stimulation (TMS) is an emerging neuromodulation technique.
Purpose of the Study:
- To explore the future clinical applications of TMS for stroke.
- To discuss the potential for personalized TMS protocols.
- To highlight the role of biomarkers and combination therapies.
Main Methods:
- Review of current literature on TMS for neurological disorders.
- Analysis of potential targets and parameters for stroke treatment.
- Discussion of patient stratification using biomarkers.
Main Results:
- TMS demonstrates potential for diverse stroke-related impairments (weakness, pain, cognitive, communicative).
- Anatomical targets and stimulation parameters will likely be customized.
- Biomarkers may predict treatment response and guide clinical decisions.
Conclusions:
- TMS is a promising future therapy for stroke.
- Personalized approaches, including biomarkers and combination therapies, are key for maximizing efficacy.
- Further research is needed to optimize TMS protocols for stroke rehabilitation.
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