Related Experiment Video

Updated: Jan 26, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.8K

Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model

Ming Chen1, Min Xu2, Chengliang Zhu3

  • 1Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, China.

Cancer Immunology, Immunotherapy : CII
|April 8, 2019
PubMed

Insights

Sirtuin2 (SIRT2) enhances liver Natural Killer (NK) cell activity against hepatocellular carcinoma (HCC). Upregulating SIRT2 in NK cells boosts their tumor-killing ability, offering a potential new avenue for HCC immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Biochemistry

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide.
  • Natural Killer (NK) cell immunity plays a vital role in controlling tumors, including HCC.
  • Understanding NK cell regulation is key for developing effective HCC immunotherapies.

Purpose of the Study:

  • To investigate the role of Sirtuin2 (SIRT2) in regulating liver NK cell function within the context of HCC.
  • To determine if SIRT2 expression impacts NK cell-mediated anti-tumor activity against HCC.

Main Methods:

  • Utilized a chemical-induced mouse model of HCC.
  • Analyzed SIRT2 expression in liver NK cells, particularly CD94+ NK cells.
  • Examined the effects of SIRT2 overexpression and knockdown on NK cell activation, cytokine production, and cytotoxic function.
  • Assessed the impact of SIRT2 on MAPK signaling pathways (Erk1/2 and p38).

Main Results:

  • Sirtuin2 (SIRT2) was found to be upregulated in liver NK cells during HCC.
  • Overexpression of SIRT2 enhanced the production of cytokines and cytotoxic mediators in activated NK cells.
  • SIRT2-overexpressing NK cells demonstrated increased tumoricidal activity against hepatoma cells.
  • SIRT2 promoted the phosphorylation of Erk1/2 and p38 MAPK in activated NK cells.
  • Knockdown of SIRT2 in liver CD94+ NK cells reduced their cytotoxic efficacy against hepatoma cells.

Conclusions:

  • Sirtuin2 (SIRT2) enhances the tumoricidal activity of liver NK cells in hepatocellular carcinoma (HCC).
  • SIRT2 signaling pathway activation is a critical mechanism for boosting NK cell-mediated anti-tumor immunity in HCC.
  • Targeting SIRT2 in NK cells represents a promising strategy for novel HCC immunotherapies.
Keywords:
Erk1/2Hepatocellular carcinomaNK cellsSirtuin2p38

More Related Videos

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma07:47

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

2.7K
Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

37.1K

Related Concept Videos

What is Natural Selection?01:32

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.6K
Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
190
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Chirality in Nature02:30

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
17.0K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
251