Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

SI Units: 2019 Redefinition

SI Units: 2019 Redefinition

Measurement is an indispensable part of analytical chemistry. The result of measurement helps quantify a substance's physical property and compare it with the physical property of another substance. Each measurement comprises two components - a number indicating the magnitude and a unit of measurement as a standard for comparison. Further, the same quantity can be measured using different units of measurement, which leads to differences in magnitude.
A standard set of units has been defined...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

Clinically Relevant Drug Product Specifications: Methods of Establishment

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension.

Aging·2025

Same author

The Divide-and-Conquer Approach to Delaying Age-Related Functional Decline: Where Are We Now?

Rejuvenation research·2023

Same author

Commentary on Some Recent Theses Relevant to Combating Aging: December 2021.

Rejuvenation research·2021

Same author

A Leader Who Leads by Example-Again.

Rejuvenation research·2021

Same author

Commentary on Some Recent Theses Relevant to Combating Aging: June 2021.

Rejuvenation research·2021

Same author

Programs, Hyperfunction, and Damage: Why Definitions and Logic Matter So Much in Biogerontology.

Rejuvenation research·2021

Search research articles

Related Experiment Video

Updated: Jan 26, 2026

Frailty Assessment in an Aging Mouse Model

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Commentary on Some Recent Theses Relevant to Combating Aging: April 2019.

Benjamin Zealley, Aubrey D N J de Grey

Rejuvenation Research

|April 9, 2019

Summary

This review covers alpha-synuclein oligomers, oligodendrocyte migration in the central nervous system, cancer signatures from monocytes and macrophages, lipoprotein oxidation, and hepatocellular carcinoma resistance.

Keywords:

aging dissertations theses

More Related Videos

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Related Experiment Videos

Last Updated: Jan 26, 2026

Frailty Assessment in an Aging Mouse Model

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Area of Science:

Neuroscience
Oncology
Immunology
Metabolic Research

Background:

This issue features diverse research topics.
Key areas include neurodegenerative diseases, cancer biomarkers, and cellular senescence.

Purpose of the Study:

To summarize recent advancements in multiple scientific fields.
To highlight novel findings in alpha-synuclein, oligodendrocyte function, cancer diagnostics, lipoprotein metabolism, and cancer therapy resistance.

Main Methods:

Review of current theses and research papers.
Analysis of cellular mechanisms, genetic profiling, and biochemical pathways.

Main Results:

Insights into alpha-synuclein oligomer behavior and antibody treatment.
Understanding the role of the Cx3cr1/cx3cl1 axis in oligodendrocyte development.
Identification of diagnostic and prognostic cancer signatures.
Exploration of lysosomal oxidation of low-density lipoproteins.
Characterization of senescence-associated secretory phenotype in hepatocellular carcinoma resistance.

Conclusions:

The reviewed theses offer significant contributions to their respective fields.
These studies advance our understanding of complex biological processes and disease mechanisms.