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Natural Polymers for Organ 3D Bioprinting
Fan Liu1,2, Qiuhong Chen3, Chen Liu4
1Department of Tissue Engineering, Center of 3D Printing & Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. liufan-sky@163.com.
Natural polymers are key to advancing three-dimensional (3D) bioprinting for creating bioartificial organs. This review highlights their properties, applications in tissue engineering, and 3D bioprinting technologies.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Three-dimensional (3D) bioprinting offers precise control over cell and biomaterial placement for bioartificial organ development.
- Natural polymers are crucial for supporting cellular functions throughout the bioprinting process.
- These polymers serve as versatile hydrogels for tissue formation and functional network construction.
Purpose of the Study:
- To review recent advancements in the use of natural polymers for bioartificial organ 3D bioprinting.
- To discuss the essential properties of 3D-printable natural polymers.
- To present successful models of 3D tissue/organ construction and relevant bioprinting technologies.
Main Methods:
- Literature review of natural polymers in 3D bioprinting.
- Analysis of polymer properties relevant to biofabrication.
- Case studies of 3D tissue and organ construction using bioprinting.
Main Results:
- Natural polymers demonstrate significant potential as cell-laden hydrogels in 3D bioprinting.
- Successful applications include homogeneous/heterogeneous tissue formation and hierarchical vascular network construction.
- Various biological, biochemical, and physiological functionalities can be realized.
Conclusions:
- Natural polymers are indispensable for the progress of bioartificial organ manufacturing via 3D bioprinting.
- Understanding polymer properties is key to optimizing tissue/organ fabrication.
- Continued research in natural polymers will drive innovation in regenerative medicine.
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