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Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell

Saleh A Almatroodi1, Mohammed A Alsahli1, Ahmad Almatroudi1

  • 1Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.

Anti-Cancer Agents in Medicinal Chemistry
|April 10, 2019
PubMed
Abstract

Insights

Garlic and its compounds show promise in cancer treatment by targeting cell signaling pathways, offering a natural approach with fewer side effects than traditional drugs.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Cancer is a complex disease involving cell signaling pathway alterations.
  • Conventional cancer drugs can cause severe toxicity and negative side effects on normal cells.

Purpose of the Study:

  • To review the chemopreventive effects of garlic and its active compounds in cancer management.
  • To focus on the modulation of cell signaling pathways by garlic constituents.

Main Methods:

  • Review of existing research on garlic and its active compounds (diallyl sulfide, diallyl trisulfide, ajoene, allicin).
  • Analysis of studies demonstrating the impact of garlic on cancer cell growth and survival.

Main Results:

  • Garlic compounds suppress cancer growth and induce cancer cell death.
  • Garlic constituents modulate cell signaling pathways, induce cell cycle arrest (G0/G1 and G2/M phases), upregulate tumor suppressor genes, inhibit angiogenesis, and promote apoptosis.

Conclusions:

  • Garlic and its active ingredients possess diverse chemopreventive activities.
  • These natural compounds offer a promising therapeutic strategy for cancer management by targeting key cellular mechanisms.
Keywords:
Garlicallicinangiogenesisapoptosiscell signalling pathwaysdiallyl disulfidediallyl trisulfide.

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