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Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate
S Zellnitz1, J T Pinto1, M Brunsteiner1
1Research Center Pharmaceutical Engineering GmbH, 8010, Graz, Austria.
Pharmaceutical Research
|April 11, 2019
Summary
API particle characteristics significantly influence tribo-electrification in dry powder inhaler (DPI) blends. Differences in solid-state, shape, and size dictate charging behavior, impacting DPI formulation performance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Physical Chemistry
Background:
- Carrier-based dry powder inhaler (DPI) formulations rely on controlled particle interactions.
- Tribo-electrification, or charge transfer during contact, significantly affects DPI performance.
- Understanding API particle properties is crucial for optimizing DPI blend behavior.
Purpose of the Study:
- To investigate how distinct Active Pharmaceutical Ingredient (API) particle characteristics influence tribo-charging.
- To analyze the charging behavior of API-excipient blends for DPI delivery.
- To elucidate the impact of API properties on electrostatic interactions in DPIs.
Main Methods:
- Model APIs (Salbutamol sulphate) were prepared via spray-drying and jet milling.
- D-mannitol served as the model carrier material.
- Particle properties were characterized, and charge analysis was performed on individual materials and blends before and after flow.
Main Results:
- Spray-dried (amorphous, spherical) Salbutamol sulphate (SBS) charged positively and more significantly than jet-milled (crystalline, acicular) SBS, which charged negatively.
- D-mannitol exhibited higher positive charging than both API forms.
- All drug-excipient blends showed negative charging, with variations observed between spray-dried and jet-milled SBS blends at different drug loads.
Conclusions:
- Distinct solid-states, particle morphology, size, and water content critically influence tribo-charging of DPI materials.
- In binary blends, the quantity and nature of fine particles appear to be key factors governing inter-particle contacts and charge evolution.
- Controlling API particle characteristics is essential for predictable electrostatic charging in DPI formulations.
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