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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Related Experiment Video

Updated: Jan 26, 2026

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
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Stimuli-Regulated Smart Polymeric Systems for Gene Therapy.

Ansuja Pulickal Mathew1, Ki-Hyun Cho2, Saji Uthaman3

  • 1Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, Korea. annsaramathew@gmail.com.

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|April 12, 2019
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Summary

Stimuli-responsive gene carriers enhance drug delivery by targeting internal body conditions like pH and temperature. This smart material approach improves therapeutic efficacy and reduces side effects for better patient outcomes.

Keywords:
enzymegene carrierinternal stimulipolyplexesstimuli-responsive systemtemperaturetransfection

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • The human body comprises diverse physiological environments with unique parameters.
  • Diseased states like inflammation or cancer alter these conditions, presenting therapeutic opportunities.
  • Conventional treatments face barriers; stimuli-responsive materials offer targeted delivery solutions.

Purpose of the Study:

  • To review internal stimuli-responsive polymeric carriers for gene expression modulation.
  • To explore how physiological triggers influence therapeutic release.
  • To highlight advancements in smart drug delivery systems.

Main Methods:

  • Focus on internal stimuli: temperature, pH, redox potential, enzymes, and biomolecules.
  • Investigate stimuli-regulated smart polymeric carriers for gene delivery.
  • Analyze the modulation of gene expression in response to physiological triggers.

Main Results:

  • Internal stimuli can be harnessed to trigger precise therapeutic release at target sites.
  • Stimuli-responsive carriers overcome physiological barriers, enhancing drug efficacy.
  • Smart polymeric systems demonstrate potential for improved treatment outcomes.

Conclusions:

  • Stimuli-responsive gene carriers offer a promising strategy for targeted therapy.
  • Understanding internal physiological triggers is key to designing effective smart drug delivery systems.
  • This approach can enhance treatment efficacy and minimize adverse effects.