Related Experiment Video
Updated: Jan 26, 2026

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry
Published on: September 15, 2020
USP7: combining tools towards selectivity
Lorina Gjonaj1, Aysegul Sapmaz, Román González-Prieto
1Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands. d.flierman@pepscan.com H.Ovaa@lumc.nl.
Abstract:
Active-site directed probes based on the ubiquitin scaffold have been successfully applied as tools to determine the levels of active deubiquitinating enzymes (DUBs). Here, we show the development of a Ub-based reagent selective for the DUB USP7. This concept can be applied for the generation of other new selective reagents.
Related Concept Videos
What is Natural Selection?
Antibiotic Selection
Types of Selection
Frequency-dependent Selection
Limits to Natural Selection
Natural Selection and Adaptation
Beyond physical adaptations,...

