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Electrospun poly-ε-caprolactone (PCL) scaffolds with β-cyclodextrin (β-CD) and its amino derivative were fabricated. Optimal fiber formation and pseudorotaxane structures were achieved using 2,2,2-Trifluoroethanol (TFE) solvent for biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Poly-ε-caprolactone (PCL) is a widely used biodegradable polymer for tissue engineering scaffolds.
  • Incorporating β-cyclodextrin (β-CD) and its derivatives can enhance scaffold properties for biomedical applications.
  • Developing robust electrospinning techniques is crucial for creating defect-free PCL-based scaffolds.

Purpose of the Study:

  • To prepare and characterize electrospun scaffolds of neat PCL, PCL/β-CD, and PCL/β-CD-NH₂.
  • To investigate the effect of different solvent systems on the electrospinning process and scaffold morphology.
  • To explore the potential of these scaffolds in the biomedical field.

Main Methods:

  • Electrospinning of PCL, PCL/β-CD, and PCL/β-CD-NH₂ formulations.
  • Solvent system screening using dimethylformamide (DMF)-tetrahydrofuran (THF), dichlormethane (DCM)-dimethyl sulfoxide (DMSO), and 2,2,2-Trifluoroethanol (TFE).
  • Characterization using X-ray diffraction (XRD), FESEM, FTIR-ATR, DSC, confocal-Raman spectroscopy, ¹HNMR, and contact angle measurements.
  • Theoretical analysis using the Hartree-Fock method with an STO-3G basis set.

Main Results:

  • Electrospun nanofibers exhibited a pseudorotaxane structure.
  • 2,2,2-Trifluoroethanol (TFE) as a solvent yielded well-formed nanofibers without defects.
  • Other solvent mixtures resulted in scaffolds with defects like molten fibers and beads.
  • Successful preparation of PCL/β-CD-NH₂ inclusion complexes.

Conclusions:

  • The choice of solvent significantly impacts the quality of electrospun PCL-based scaffolds.
  • 2,2,2-Trifluoroethanol (TFE) is a suitable solvent for fabricating defect-free PCL/β-CD-NH₂ nanofibers.
  • These PCL/β-CD-NH₂ scaffolds show promise for biomedical applications.