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Related Experiment Video

Updated: Jan 26, 2026

Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy
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Polypoidal Choroidal Vasculopathy.

Raquel Goldhardt1,2, Bradley Simon Rosen3

  • 1Miami Veterans Administration Medical Center, Miami, FL, USA.

Current Ophthalmology Reports
|April 13, 2019
PubMed
Summary

Polypoidal choroidal vasculopathy (PCV) treatment is evolving. Combination therapy shows similar visual outcomes to anti-VEGF alone, but long-term recurrence data is needed for optimal polypoidal choroidal vasculopathy management.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Vascular Biology

Background:

  • Polypoidal choroidal vasculopathy (PCV) presents with characteristic polypoidal dilatations and branching vascular networks, leading to recurrent hemorrhages and leakage.
  • PCV is often considered a subtype of age-related macular degeneration but is increasingly recognized within the spectrum of pachychoroid diseases.
  • The condition is associated with a poor visual prognosis, necessitating advancements in treatment strategies.

Purpose of the Study:

  • To review recent developments in the therapeutic approaches for active polypoidal choroidal vasculopathy (PCV).
  • To evaluate the efficacy of current and emerging treatments for PCV, focusing on visual outcomes and disease control.

Main Methods:

  • Systematic review of recent research on PCV pathogenesis and treatment.
Keywords:
branching vascular networkpolypoidal choroidal vasculopathyretinal detachmentserosanguinous retinal pigment epithelium detachmentvitreous hemorrhage

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  • Analysis of clinical trial data comparing different therapeutic modalities, including photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) agents.

    • Main Results:

    • New insights into PCV pathogenesis suggest its relation to pachychoroid conditions.
    • Combination therapy (PDT plus anti-VEGF) demonstrates higher polyp closure rates but not necessarily superior visual acuity outcomes compared to anti-VEGF monotherapy.
    • Current evidence indicates non-inferiority of anti-VEGF monotherapy versus combination therapy regarding final visual acuity.

    Conclusions:

    • Polypoidal choroidal vasculopathy (PCV) remains a significant clinical challenge with evolving classification and treatment paradigms.
    • While combination therapy may achieve higher polyp closure, anti-VEGF monotherapy offers comparable visual acuity outcomes.
    • Further comparative data on long-term recurrence rates are crucial for refining preferred treatment strategies for PCV.