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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
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Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
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Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
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Biocompatible Lipopeptide-Based Antibacterial Hydrogel.

Anindyasundar Adak1, Subhajit Ghosh1, Varsha Gupta1

  • 1Organic & Medicinal Chemistry Division , CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road , Jadavpur, Kolkata 700032 , West Bengal , India.

Biomacromolecules
|April 13, 2019
PubMed
Summary
This summary is machine-generated.

This study presents a novel biocompatible hydrogel designed from a hexapeptide. This antibacterial hydrogel effectively inhibits bacterial growth while supporting mammalian cell culture, offering dual biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cell Biology

Background:

  • Developing biocompatible materials is crucial for advanced biomedical applications.
  • Hydrogels offer versatile platforms for drug delivery and tissue engineering.
  • Antibacterial materials are needed to combat rising infections.

Purpose of the Study:

  • To design and fabricate a novel biocompatible hydrogel using a hexapeptide.
  • To evaluate the hydrogel's antibacterial properties and its potential for mammalian cell culture.

Main Methods:

  • Amphiphilic hexapeptide design with specific functional groups.
  • Hydrogel fabrication via self-assembly into fibrillar networks.
  • Assessment of antibacterial activity through bacterial membrane rupture.
  • Evaluation of biocompatibility using cell viability and hemolytic assays.

Main Results:

  • The designed hexapeptide self-assembled into a biocompatible hydrogel.
  • The hydrogel demonstrated effective inhibition of bacterial growth by rupturing cell membranes.
  • The material showed stability against enzymatic degradation (Proteinase K).
  • Cell viability assays confirmed non-cytotoxic behavior, supporting mammalian cell growth.
  • Hemolytic assays indicated minimal damage to human red blood cells.

Conclusions:

  • The novel hexapeptide-based hydrogel exhibits potent antibacterial activity.
  • The hydrogel provides a biocompatible scaffold for mammalian cell culture.
  • This material holds promise for dual applications as an antibacterial biomaterial and a cell culture scaffold.